Effect Of Ethanol Extract Of Arumanis Mango Leaves (Mangifera Indica L) On Egf, Mda, And Wound Area Levels In Male White Rats Wistar Strain (Rattus Norvegicus) Diabetic Ulcer Model

Abstract

Diabetes Mellitus (DM) is one of the leading causes of death in Indonesia. Diabetes Mellitus is considered a major health problem and has been a concern since the early 1980s. The prevalence of DM in Indonesia is 6.2%, with more than 10 million people living with DM. This makes Indonesia one of the top ten countries with the highest number of DM patients in 2013. The general objective of this research is to analyze the effects of ethanol extract of Arumanis mango leaves (Mangifera indica L) on EGF levels, MDA, and wound area in male white Wistar rats (Rattus norvegicus) diabetic ulcer model. The research design using a posttest only controlled group design is experimental laboratory on male white Wistar rats with diabetes mellitus. This design allows researchers to measure the effect of treatment (intervention) on the experimental group by comparing the experimental group with the control group. The results of this study obtained phytochemical screening: Alkaloids, Phenols, Saponins, Tannins, and Flavonoids.