Association Of Thyroid Function And Non-Alcoholic Fatty Liver Disease In Type 2 Diabetic Patients

Authors

  • Dr Avinash H R Author
  • Dr Swetha Rajoli Author
  • Dr Bhargav V Bhat Author

DOI:

https://doi.org/10.53555/AJBR.v28i1.6638

Keywords:

Type 2 diabetes mellitus, Non-alcoholic fatty liver disease, Thyroid hormones, FIB4

Abstract

Background: The objective of this study is to analyse the correlation between the thyroid hormones and non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients with normal thyroid function.

Objective: To correlate the thyroid hormone levels with NAFLD in Type 2 diabetes patients with normal thyroid state and to predict liver fibrosis risk using FT3 FT4 levels and FIB 4 score

Methods: Totally 114 T2DM patients with normal thyroid function participated in this research and were divided into T2DM without NAFLD (62 cases) group and T2DM with NAFLD (52 cases) group.FT3, FT4 TSH and various other biochemical parameters were analysed between T2DM with and without NAFLD.

Results: The results indicated that the levels of free triiodothyronine FT4 was significantly lower. Though it was not statistically significant, the FT3 level was higher in T2DM with NAFLD group than that in T2DM without NAFLD group. There was negative correlation between FT 3 and FIB4 score and positive correlation between FT4 and FIB4 score predicting the risk of progressive liver fibrosis, however they were not statistically significant.

Conclusion: There is a certain correlation between thyroid hormone levels and NAFLD in T2DM patients, suggesting that the assessment of thyroid hormone levels in T2DM patients with normal thyroid function could be helpful in the prevention and treatment of NAFLD.

Author Biographies

  • Dr Avinash H R

    Assistant professor, department of general medicine, SABVMCRI, Bangalore

  • Dr Swetha Rajoli

    Assistant professor, assistant professor department of Anesthesia, ESIC PGIMSR, Bangalore, Postal address: 402 B Affinity Sowparnika apartment, Yelahanka, Bangalore -560064

  • Dr Bhargav V Bhat

    Senior resident, department of General Medicine, Chandramma Dayanand Sagar Institute of Medical Education and Research, Bangalore 

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Published

2025-03-02

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Section

Original Article

How to Cite

Association Of Thyroid Function And Non-Alcoholic Fatty Liver Disease In Type 2 Diabetic Patients. (2025). African Journal of Biomedical Research, 28(1), 405-414. https://doi.org/10.53555/AJBR.v28i1.6638