The Anti-Osteoporotic Effect of Moringa Oleifera Leaves On Glucocorticoids-Induced Osteoporosis In Female Rats

Abstract

Glucocorticoid-induced osteoporosis and fragility fractures are a significant human and social burden worldwide. All existing pharmaceutical remedies have numerous side effects and are expensive. Thus, the current study sought to assess the anti-osteoporotic benefits of Moringa oleifera (MO) leaves in female rats. Thirty-five adult female albino rats (180 ± 10 g) were divided into two groups, the first (n = 7) as a normal control group fed on a baseline diet only, and the second (n = 28) were injected with dexamethasone (1 ml/100g) once a day for 6 weeks to induce osteoporosis. The second main group (n = 7) was broken into four subgroups. As a positive control, Subgroup 1 was given a baseline diet. The other three subgroups treated with dried moringa leaves (2.5, 5 and 10%), respectively. Results indicated that, Supplementation with MO leaves significantly enhanced (P<0.05) serum Ca and P. There was a considerable increase (P<0.05) in serum free thyroxin (T4) and drop in parathormone (PTH) in osteoporotic rats. Femur bone mineral density (BMD) increased dramatically. It caused significant improved lipid profile and liver function. Conclusion: The present research suggested that Moringa oleifera leaves have anti-osteoporotic effect.