Molecular Phenotypes of Ductal Carcinoma of The Breast And Its Association With Histopathological Prognostic Markers

Authors

  • Santosh Kumar Sharma Author
  • Sompal Singh Author
  • Ratna Chopra Author
  • Sarvesh Rustagi Author
  • Pramod Rawat Author
  • Sanjay Kumar Author

DOI:

https://doi.org/10.53555/AJBR.v28i1.5264

Keywords:

Breast cancer, molecular phenotypes, prognostic markers, IDC-NST

Abstract

Background: Globally, breast carcinoma is a major cause of cancer-associated deaths among women, which is significantly impacting India. Compared to women in developed countries, Indian women often present with breast cancer (BC) at younger ages and with more aggressive forms. This study focused to determine the prevalence of different molecular phenotypes and their associations with histological prognostic markers in infiltrating ductal carcinoma-no special type (IDC-NST) in an Indian population.

Materials and methods: An analytical cross-sectional study was conducted on 351 BC patients at a tertiary care hospital. Immunohistochemistry was used to identify molecular phenotypes: triple-negative breast cancer (TNBC), HER2-enriched, luminal-A, and luminal-B. Clinical and histopathological data, including age, multifocality status, lymph node status, BR grade, tumor volume, pathological stage, microvessel density (MVD), and proliferation index (Ki-67), were assessed for associations with molecular phenotypes.

Results: The most common molecular phenotype was TNBC, while luminal-B was second most. Significant differences were observed in tumor grade, tumor volume, tumor stage, percentage of positive lymph nodes, MVD, and Ki-67 score among the molecular phenotypes. The luminal A subgroup had significantly lower tumor volumes and Ki-67 scores, while the HER2-enriched subtype had increased lymph node positivity.

Conclusion: This study highlights the distinct prevalence and prognostic features of molecular subtypes of IDC-NST in an Indian cohort. These findings underscore the importance of molecular profiling in guiding treatment strategies and improving prognostic assessments for BC patients in India.

 

Author Biographies

  • Santosh Kumar Sharma

    Department of Life science, School of Basic Sciences and Research, Sharda University, Greater NOIDA, Uttar Pradesh, 201310, India.

  • Sompal Singh

    Department of Pathology, Hindu Rao Hospital & NDMC Medical College, Delhi-110007, India

  • Ratna Chopra

    Department of Surgery, Hindu Rao Hospital and NDMC Medical College, Delhi-110007, India.

  • Sarvesh Rustagi

    Department of Food Technology, School of Applied and Life science, Uttaranchal University, Dehradun (Uttarakhand)- 248007, India.

  • Pramod Rawat

    Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun- 248002, India.

  • Sanjay Kumar

    Department of Life science, School of Basic Sciences and Research, Sharda University, Greater NOIDA, Uttar Pradesh- 201310, India

Downloads

Published

2024-12-19

Issue

Section

Research Article

How to Cite

Molecular Phenotypes of Ductal Carcinoma of The Breast And Its Association With Histopathological Prognostic Markers. (2024). African Journal of Biomedical Research, 28(1), 102-113. https://doi.org/10.53555/AJBR.v28i1.5264